For the past twenty years, localities interested in capitalizing on the presence of technology firms have pursued a “technopolis strategy” for sustaining economic development. Dozens of these metropolitan areas from several countries have formed the World Technopolis Association (WTA). In a parallel but very separate development, NAFTA, Mercosur, GATT, WTO, and other free trade efforts worldwide have attempted to regularize trade rules among nations. Are these trends in harmony or in conflict? On their face, WTO’s efforts to treat with nation-states rather than regional “citistates” look quaintly old-fashioned, and its discussions of prohibiting differential tax treatment of companies would eliminate exactly the incentives that successful citistates have used to build viable industrial clusters. On the other hand, local technology clusters have benefited from the freer movement of people and material made possible by free trade agreements.